A disintegrin and metalloproteinase with thrombospondin motifs 1 (Protein name
), ATS1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
ADAMTS1(KIAA1346;METH1);
Protein name:
A disintegrin and metalloproteinase with thrombospondin motifs 1(ADAM-TS 1;ADAM-TS1;ADAMTS-1);
Alternative:
METH-1;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Function:
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
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Precision
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Recovery
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Linearity
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References
1.
"Cloning, characterization and mapping on human chromosome 21 of the orthologue of murine Adamts-1." Casas C.
,
Pritchard M.A.
,
Estivill X.
,
Arbones M.L.
Submitted (1999-07) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT PRO-227
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Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT PRO-227;FUNCTION
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 418-967
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Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 253-548 ALONE AND IN COMPLEX WITH INHIBITOR;ACTIVE SITE;COFACTOR;ZINC-BINDING SITES;CALCIUM-BINDING SITES;DISULFIDE BONDS